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Tumor-Derived Microvesicles Modulate Antigen Cross-Processing via Reactive Oxygen Species-Mediated Alkalinization of Phagosomal Compartment in Dendritic Cells

Dendritic cells (DCs) are the only antigen-presenting cells able to prime naïve T cells and cross-prime antigen-specific CD8+ T cells. Their functionality is a requirement for the induction and maintenance of long-lasting cancer immunity. Albeit intensively investigated, the in vivo mechanisms under...

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Principais autores: Federico Battisti, Chiara Napoletano, Hassan Rahimi Koshkaki, Francesca Belleudi, Ilaria Grazia Zizzari, Ilary Ruscito, Sara Palchetti, Filippo Bellati, Pierluigi Benedetti Panici, Maria Rosaria Torrisi, Giulio Caracciolo, Fabio Altieri, Marianna Nuti, Aurelia Rughetti
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017-09-01
Serier:Frontiers in Immunology
Fag:
microvesicles
dendritic cells
antigen-processing
phagosome
radical oxigen species
immune response to cancer
Online adgang:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01179/full
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