Tranexamic acid did not attenuate the acute rise in plasma syndecan-1 in a severely injured cohort: a laboratory analysis of the PATCH clinical trial

Abstract Background Injury to the vascular endothelium occurs in up to 34% of patients acutely following severe traumatic injury and can be quantified clinically by measuring the plasma concentration of syndecan-1 (SDC-1). Tranexamic acid (TXA) attenuates endothelial damage in animal and cell cultur...

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Principais autores:	Elissa M. Milford, Dusan Marjanovic, Heidi Ho, Steven Wallis, Dominik F. Draxler, Biswadev Mitra, Russell L. Gruen, Robert Medcalf, Stephen Bernard, Colin McArthur, Marc Meagele, Brian Burns, Dashiell Gantner, Michael C. Reade
Formato:	Artigo
Idioma:	Inglês
Publicado:	SpringerOpen 2025-07-01
Series:	Intensive Care Medicine Experimental
Assuntos:	Trauma Tranexamic acid Glycocalyx Endothelium Syndecan-1
Acceso en liña:	https://doi.org/10.1186/s40635-025-00784-2
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