Age-Related Transcriptional Deregulation of Genes Coding Synaptic Proteins in Alzheimer's Disease Murine Model: Potential Neuroprotective Effect of Fingolimod

Alzheimer's disease (AD) induces time-dependent changes in sphingolipid metabolism, which may affect transcription regulation and neuronal phenotype. We, therefore, analyzed the influence of age, amyloid β precursor protein (AβPP), and the clinically approved, bioavailable sphingosine-1-phosphate re...

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Hlavní autoři:	Henryk Jęśko, Iga Wieczorek, Przemysław Leonard Wencel, Magdalena Gąssowska-Dobrowolska, Walter J. Lukiw, Robert Piotr Strosznajder
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2021-07-01
Edice:	Frontiers in Molecular Neuroscience
Témata:	aging Alzheimer's disease amyloid β FTY720/fingolimod neurodegeneration sphingolipids
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fnmol.2021.660104/full
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