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Molecular regulation and therapeutic targeting of MYCN in neuroblastoma: a comprehensive review

MYCN amplification defines a highly aggressive subtype of neuroblastoma and is strongly associated with poor clinical outcomes. Due to the intrinsically disordered structure of the N-Myc protein, it remains largely undruggable. This review provides a comprehensive summary of the molecular regulatory...

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Principais autores: Yi Chen, Huixian Yang, Lirong Xiao, Naihong Yan, Ming Zhang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-10-01
Serier:Frontiers in Cell and Developmental Biology
Fag:
MYCN amplification
N-myc
MYCN protein
neuroblastoma
epigenetic regulation
PROTAC
Online adgang:https://www.frontiersin.org/articles/10.3389/fcell.2025.1683331/full
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