Neurons derived from sporadic Alzheimer’s disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation

Abstract Background Alzheimer’s disease (AD) is the most common type of dementia, affecting one in eight adults over 65 years of age. The majority of AD cases are sporadic, with unknown etiology, and only 5% of all patients with AD present the familial monogenic form of the disease. In the present s...

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Detalhes bibliográficos

Principais autores:	Anna Ochalek, Balázs Mihalik, Hasan X. Avci, Abinaya Chandrasekaran, Annamária Téglási, István Bock, Maria Lo Giudice, Zsuzsanna Táncos, Kinga Molnár, Lajos László, Jørgen E. Nielsen, Bjørn Holst, Kristine Freude, Poul Hyttel, Julianna Kobolák, András Dinnyés
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2017-12-01
coleção:	Alzheimer’s Research & Therapy
Assuntos:	Familial Alzheimer’s disease Sporadic Alzheimer’s disease Induced pluripotent stem cells Amyloid β TAU pathology Hyperphosphorylation
Acesso em linha:	http://link.springer.com/article/10.1186/s13195-017-0317-z
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