Altered CYP19A1 and CYP3A4 Activities Due to Mutations A115V, T142A, Q153R and P284L in the Human P450 Oxidoreductase

All cytochromes P450s in the endoplasmic reticulum rely on P450 oxidoreductase (POR) for their catalytic activities. Mutations in POR cause metabolic disorders of steroid hormone biosynthesis and affect certain drug metabolizing P450 activities. We studied mutations A115V, T142A, Q153R identified in...

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Hlavní autoři:	Sameer S. Udhane, Shaheena Parween, Norio Kagawa, Amit V. Pandey
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2017-08-01
Edice:	Frontiers in Pharmacology
Témata:	POR P450 oxidoreductase CYP19A1 CYP3A4 polymorphisms protein–protein interaction
On-line přístup:	http://journal.frontiersin.org/article/10.3389/fphar.2017.00580/full
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