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Interactive Effects of Glucocorticoids and Cytochrome P450 Polymorphisms on the Plasma Trough Concentrations of Voriconazole

Aims: To explore the interactive influence of glucocorticoids and cytochrome P450 (CYP450) polymorphisms on voriconazole (VRC) plasma trough concentrations (Cmin) and provide a reliable basis for reasonable application of VRC.Methods: A total of 918 VRC Cmin from 231 patients was collected and quant...

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Principais autores: Su-jie Jia, Ke-qin Gao, Pan-hao Huang, Ren Guo, Xiao-cong Zuo, Qing Xia, Shuang-yao Hu, Zhen Yu, Yue-liang Xie
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-05-01
coleção:Frontiers in Pharmacology
Assuntos:
glucocorticoids
CYP2C19
CYP3A4
CYP3A5
voriconazole
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2021.666296/full
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