The Cytochrome P450 OxyA from the Kistamicin Biosynthesis Cyclization Cascade is Highly Sensitive to Oxidative Damage

Cytochrome P450 enzymes (P450s) are a superfamily of monooxygenases that utilize a cysteine thiolate–ligated heme moiety to perform a wide range of demanding oxidative transformations. Given the oxidative power of the active intermediate formed within P450s during their active cycle, it is remarkabl...

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Detalhes bibliográficos

Principais autores:	Anja Greule, Thierry Izoré, Daniel Machell, Mathias H. Hansen, Melanie Schoppet, James J. De Voss, Louise K. Charkoudian, Ralf B. Schittenhelm, Jeffrey R. Harmer, Max J. Cryle
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-04-01
Colecção:	Frontiers in Chemistry
Assuntos:	cytochrome P450 glycopeptide antibiotic biosynthesis kistamicin heme biosynthesis
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fchem.2022.868240/full
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