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CircZFAND6 suppresses gastric cancer metastasis and reduces resistance to TKI therapy

Abstract Background Peritoneal metastasis, the most common mode of dissemination in gastric cancer (GC), is characterized by resistance to treatment and a poor prognosis. Accumulating evidence indicates that circular RNAs (circRNAs) play a significant role in tumor progression. However, the role of...

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Principais autores: Zi-Jian Deng, Li-Ying OuYang, Jian-Ping Guo, Huan-Ting Yao, Jun-Jie Liu, Shu-Li Ma, Dong-Wen Chen, Xian-Zhe Li, Lei Lian, Jun-Sheng Peng, Shi Chen
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2025-12-01
coleção:Molecular Cancer
Assuntos:
Gastric cancer
Metastasis
TKI
Gefitinib resistance
CircRNA
Wnt/β-catenin
Acesso em linha:https://doi.org/10.1186/s12943-025-02478-5
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