Approaches to the definition of macromolecular aggregates in glatiramoids

The approaches to the selection of the optimal chromatographic conditions to assess the content of high molecular weight aggregates in glatiramer acetate - compounds belonging to nonbiological medicines of complex chemical structure - are described. It is found that accelerated aggregate formation o...

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Bibliographic Details

Main Authors:	Yu. V. Olefir, A. I. Lutseva, O. A. Vaganova, A. A. Bendryshev, T. A. Efremova
Format:	Artigo
Language:	Russo
Published:	Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’) 2018-02-01
Series:	Регуляторные исследования и экспертиза лекарственных средств
Subjects:	глатирамоиды глатирамера ацетат эксклюзионная хроматография высокомолекулярные соединения агрегаты glatiramoids glatiramer acetate size-exclusion chromatography macromolecular compounds aggregates
Online Access:	https://www.vedomostincesmp.ru/jour/article/view/59
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