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Sympathetic neurons secrete retrogradely transported TrkA on extracellular vesicles

Abstract Proper wiring of the peripheral nervous system relies on neurotrophic signaling via nerve growth factor (NGF). NGF secreted by target organs (i.e. eye) binds to the TrkA receptor expressed on the distal axons of postganglionic neurons. Upon binding, TrkA is internalized into a signaling end...

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Bibliografski detalji
Glavni autori: Ashley J. Mason, Austin B. Keeler, Farah Kabir, Bettina Winckler, Christopher Deppmann
Format: Artigo
Jezik:Inglês
Izdano: Nature Portfolio 2023-03-01
Serija:Scientific Reports
Online pristup:https://doi.org/10.1038/s41598-023-30728-3
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