A quest for the stereo-electronic requirements for selective agonism for the neurotrophin receptors TrkA and TrkB in 17-spirocyclic-dehydroepiandrosterone derivatives

IntroductionThe neurotrophin system plays a pivotal role in the development, morphology, and survival of the nervous system, and its dysregulation has been manifested in numerous neurodegenerative and neuroinflammatory diseases. Neurotrophins NGF and BDNF are major growth factors that prevent neuron...

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Principais autores:	Daniele Narducci, Despoina Charou, Thanasis Rogdakis, Ioanna Zota, Vivi Bafiti, Maria Zervou, Theodora Katsila, Achille Gravanis, Kyriakos C. Prousis, Ioannis Charalampopoulos, Theodora Calogeropoulou
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2023-09-01
Series:	Frontiers in Molecular Neuroscience
Assuntos:	neurotrophin mimetics TrkA TrkB receptor agonists signaling neuroprotection
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fnmol.2023.1244133/full
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