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Identification of peptide mimotopes of Trypanosoma brucei gambiense variant surface glycoproteins.

BACKGROUND: The current antibody detection tests for the diagnosis of gambiense human African trypanosomiasis (HAT) are based on native variant surface glycoproteins (VSGs) of Trypanosoma brucei (T.b.) gambiense. These native VSGs are difficult to produce, and contain non-specific epitopes that may...

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Principais autores: Liesbeth Carolien Van Nieuwenhove, Stijn Rogé, Fatima Balharbi, Tessa Dieltjens, Thierry Laurent, Yves Guisez, Philippe Büscher, Veerle Lejon
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2011-06-01
Serier:PLoS Neglected Tropical Diseases
Online adgang:http://europepmc.org/articles/PMC3114753?pdf=render
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