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Advanced biomanufacturing and evaluation of adeno-associated virus

Abstract Recombinant adeno-associated virus (rAAV) has been developed as a safe and effective gene delivery vehicle to treat rare genetic diseases. This study aimed to establish a novel biomanufacturing process to achieve high production and purification of various AAV serotypes (AAV2, 5, DJ, DJ8)....

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Principais autores: Kai Chen, Seulhee Kim, Siying Yang, Tanvi Varadkar, Zhuoxin Zora Zhou, Jiashuai Zhang, Lufang Zhou, Xiaoguang Margaret Liu
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-02-01
Serier:Journal of Biological Engineering
Fag:
Adeno-associated virus (AAV)
Biomanufacturing
Bioproduction
Purification
Online adgang:https://doi.org/10.1186/s13036-024-00409-4
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