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Mitochondrial DNA released from pyroptotic synovial macrophages via DDIT3-mediated mitophagy aggravates osteoarthritis progression

Objective: Emerging evidence has shown that inflammatory synovial macrophage and anabolism-impaired chondrocytes play essential roles in osteoarthritis (OA). The present work aims at uncovering the pathogenic mechanism of how the damage-associated molecular patterns (DAMPs) released from inflammator...

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Kaydedildi:
Asıl Yazarlar: Chang Yang, Jin Ke, Qiongdong Xu, Wei Dong, Wenqian Yu, Yan Wang, Jiawei Wang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2026-01-01
Seri Bilgileri:Journal of Orthopaedic Translation
Konular:
Cartilage degeneration
DDIT3
mtDNA release
Osteoarthritis
Pyroptotic macrophages
Online Erişim:http://www.sciencedirect.com/science/article/pii/S2214031X25001925
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