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Human Pluripotent Stem Cell-Based Models for Hirschsprung Disease: From 2-D Cell to 3-D Organoid Model

Hirschsprung disease (HSCR) is a complex congenital disorder caused by defects in the development of the enteric nervous system (ENS). It is attributed to failures of the enteric neural crest stem cells (ENCCs) to proliferate, differentiate and/or migrate, leading to the absence of enteric neurons i...

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Principais autores: Kathy Nga-Chu Lui, Elly Sau-Wai NGAN
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-10-01
Serier:Cells
Fag:
Hirschsprung disease
induced pluripotent stem cells
disease modeling
enteric nervous system
colonic organoids
Online adgang:https://www.mdpi.com/2073-4409/11/21/3428
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