Baicalein ameliorates cognitive decline induced by chronic cerebral hypoperfusion through the SIRT1-mediated Notch1 pathway to improve angiogenesis and suppress neuroinflammation

IntroductionThe potential for therapeutic strategies that promote angiogenesis and suppress neuroinflammation to ameliorate cognitive decline induced by chronic cerebral hypoperfusion (CCH) has led to their recognition as promising therapeutic targets for vascular dementia (VD). The SIRT1-mediated N...

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Autori principali:	Meixi Li, Jiaxi Song, Xiaoli Niu, Feng Mo, Xiaohua Xie, Xiuqin Li, Yu Yin, Tianjun Wang, Xiujuan Song, Jingze Liu, Peiyuan Lv
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2025-04-01
Serie:	Frontiers in Aging Neuroscience
Soggetti:	vascular dementia (VD) baicalein angiogenesis neuroinflammation SIRT1-mediated Notch1 pathway
Accesso online:	https://www.frontiersin.org/articles/10.3389/fnagi.2025.1521353/full
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