Lung adenocarcinoma and colorectal cancer as double primary malignancies reveal lynch syndrome: a case report of germline MLH1 mutation with response to immunotherapy and familial aggregation

Lynch syndrome (LS), also known as hereditary nonpolyposis colorectal cancer, is a genetic condition that increases the risk of developing colorectal cancer (CRC) and other cancers due to defective DNA mismatch repair (dMMR). This article reports a case of a patient who developed lung adenocarcinoma...

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Hlavní autoři:	Menglei Wang, Haoyue Xue, Jiamin Hong, Qi Liu, Keke Hu, Chang Shu, Jinghua Wang, Yu Long, Yehong Han, Xuefei Yang, Jinhua Lu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2026-01-01
Edice:	Frontiers in Immunology
Témata:	dMMR immunotherapy lynch syndrome MLH1 retrospective MMR testing
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1709036/full
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