PTEN mutant non-small cell lung cancer require ATM to suppress pro-apoptotic signalling and evade radiotherapy

Abstract Background Despite advances in treatment of patients with non-small cell lung cancer, carriers of certain genetic alterations are prone to failure. One such factor frequently mutated, is the tumor suppressor PTEN. These tumors are supposed to be more resistant to radiation, chemo- and immun...

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Detalhes bibliográficos

Principais autores:	Thomas Fischer, Oliver Hartmann, Michaela Reissland, Cristian Prieto-Garcia, Kevin Klann, Nikolett Pahor, Christina Schülein-Völk, Apoorva Baluapuri, Bülent Polat, Arya Abazari, Elena Gerhard-Hartmann, Hans-Georg Kopp, Frank Essmann, Mathias Rosenfeldt, Christian Münch, Michael Flentje, Markus E. Diefenbacher
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2022-04-01
coleção:	Cell & Bioscience
Assuntos:	PTEN ATM IR NSCLC Radiotherapy Cancer
Acesso em linha:	https://doi.org/10.1186/s13578-022-00778-7
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