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How Autoantibodies Regulate Osteoclast Induced Bone Loss in Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic inflammatory disease, characterized by autoimmunity that triggers joint inflammation and tissue destruction. Traditional concepts of RA pathogenesis have strongly been focused on inflammation. However, more recent evidence suggests that autoimmunity per se modu...

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Principais autores: Ulrike Steffen, Georg Schett, Aline Bozec
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019-07-01
Serier:Frontiers in Immunology
Fag:
rheumatoid factor (RF)
autoantibodies against citrullinated proteins (ACPA)
osteoclasts
rheumatoid arthritis
cytokines
Online adgang:https://www.frontiersin.org/article/10.3389/fimmu.2019.01483/full
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