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PIKfyve regulates melanosome biogenesis.

PIKfyve, VAC14, and FIG4 form a complex that catalyzes the production of PI(3,5)P2, a signaling lipid implicated in process ranging from lysosome maturation to neurodegeneration. While previous studies have identified VAC14 and FIG4 mutations that lead to both neurodegeneration and coat color defect...

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Principais autores: Marc C Liggins, Jessica L Flesher, Sohail Jahid, Priya Vasudeva, Victoria Eby, Shunsuke Takasuga, Junko Sasaki, Takehiko Sasaki, Raymond E Boissy, Anand K Ganesan
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2018-03-01
Serier:PLoS Genetics
Online adgang:https://escholarship.org/uc/item/3rg2c4qs
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