Suppression of Tau Phosphorylation Induces Neurotoxicity, Causing Developmental Defects and Degeneration in <i>C. elegans</i>

Tau hyperphosphorylation is a hallmark of tauopathies and is closely associated with neurodegeneration. While targeting kinases and phosphatases to suppress tau phosphorylation has become an increasingly attractive therapeutic approach, the functional significance of tau phosphorylation and the pote...

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Autori principali:	Man Pok Lu, Yi Rong, Jingyi Wang, Xiaochun Yu, Hongjiang Liu, Yingjie Wu, Minxing Zhang, Yining Chen, Yidong Li, Yuner Yan, Aiden Liu, Zhaoyu Li
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2026-04-01
Serie:	Cells
Soggetti:	<i>C. elegans</i> tau phosphorylation hTauE14 hTauAP C-terminal region (CTR) microtubule-binding domain (MTB)
Accesso online:	https://www.mdpi.com/2073-4409/15/9/793
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