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C-di-AMP sensitizes colorectal cancer to CD47 antibodies by activating NF-κB to promote macrophage phagocytosis

Abstract Objective Developing effective therapeutic strategies for colorectal cancer (CRC) presents a significant clinical challenge. Although immune checkpoint blockade therapies, such as the CD47 blockade, have shown promise, their efficacy is often limited by suboptimal responses and associated t...

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Auteurs principaux: Yu Hao, Yu Fan, Hongzhi He, Zhi Zeng, Yawen Zong, Zhenzhou Yang, Bolei Li, Lei Cheng
Format: Artigo
Langue:Inglês
Publié: BMC 2026-01-01
Collection:Cell Communication and Signaling
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Accès en ligne:https://doi.org/10.1186/s12964-026-02703-8
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