Genome-wide probing of eukaryotic nascent RNA structure elucidates cotranscriptional folding and its antimutagenic effect

Abstract The transcriptional intermediates of RNAs fold into secondary structures with multiple regulatory roles, yet the details of such cotranscriptional RNA folding are largely unresolved in eukaryotes. Here, we present eSPET-seq (Structural Probing of Elongating Transcripts in eukaryotes), a met...

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Hlavní autoři:	Gongwang Yu, Yao Liu, Zizhang Li, Shuyun Deng, Zhuoxing Wu, Xiaoyu Zhang, Wenbo Chen, Junnan Yang, Xiaoshu Chen, Jian-Rong Yang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2023-09-01
Edice:	Nature Communications
On-line přístup:	https://doi.org/10.1038/s41467-023-41550-w
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