Genome-wide probing of eukaryotic nascent RNA structure elucidates cotranscriptional folding and its antimutagenic effect

Abstract The transcriptional intermediates of RNAs fold into secondary structures with multiple regulatory roles, yet the details of such cotranscriptional RNA folding are largely unresolved in eukaryotes. Here, we present eSPET-seq (Structural Probing of Elongating Transcripts in eukaryotes), a met...

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Autores principales:	Gongwang Yu, Yao Liu, Zizhang Li, Shuyun Deng, Zhuoxing Wu, Xiaoyu Zhang, Wenbo Chen, Junnan Yang, Xiaoshu Chen, Jian-Rong Yang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2023-09-01
Colección:	Nature Communications
Acceso en línea:	https://doi.org/10.1038/s41467-023-41550-w
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