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LncMAPK6 drives MAPK6 expression and liver TIC self-renewal

Abstract Background Liver tumor initiating cells (TICs) have self-renewal and differentiate capacities, and largely contribute to tumor initiation, metastasis and drug resistance. MAPK signaling is a critical pathway in many biological processes, while its role in liver TICs hasn’t been explored. Me...

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Principais autores: Guanqun Huang, Hui Jiang, Yueming He, Ye Lin, Wuzheng Xia, Yuanwei Luo, Min Liang, Boyun Shi, Xinke Zhou, Zhixiang Jian
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2018-05-01
Serier:Journal of Experimental & Clinical Cancer Research
Fag:
MAPK6
lncMAPK6
Liver TIC
Self-renewal
Tumor targeting
Online adgang:http://link.springer.com/article/10.1186/s13046-018-0770-y
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