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LncRNA PVT1 activated by TGF-β1/Smad3 facilitates proliferation and metastasis of hepatocellular carcinoma via upregulating Smad6 and NRG1

Abstract Background Hepatocellular carcinoma (HCC) significantly affects the patient’s physical and mental health. Long non-coding RNA plasmacytoma variant translocation 1 (lncRNA PVT1) has been associated with the progression of HCC. However, the current effectiveness of HCC treatment is considered...

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Autors principals: Shuaihui Wu, Qian Cheng, Yang Shi, Kunlei Wang, Zhinan Chen, Xinyin Li, Ping Jiang, Zhixiang Cheng, Zhiyong Yang, Bo Liao
Format: Artigo
Idioma:Inglês
Publicat: BMC 2025-05-01
Col·lecció:Journal of Translational Medicine
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Accés en línia:https://doi.org/10.1186/s12967-025-06229-4
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