Enhanced cytotoxicity of natural killer cells following the acquisition of chimeric antigen receptors through trogocytosis.

Natural killer (NK) cells have the capacity to target tumors and are ideal candidates for immunotherapy. Viral vectors have been used to genetically modify in vitro expanded NK cells to express chimeric antigen receptors (CARs), which confer cytotoxicity against tumors. However, use of viral transdu...

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Auteurs principaux:	Fu-Nan Cho, Tsung-Hsien Chang, Chih-Wen Shu, Ming-Chin Ko, Shuen-Kuei Liao, Kang-Hsi Wu, Ming-Sun Yu, Shyh-Jer Lin, Ying-Chung Hong, Chien-Hsun Chen, Chien-Hui Hung, Yu-Hsiang Chang
Format:	Artigo
Langue:	Inglês
Publié:	Public Library of Science (PLoS) 2014-01-01
Collection:	PLoS ONE
Accès en ligne:	http://europepmc.org/articles/PMC4196898?pdf=render
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