Expanding Roles of the E2F-RB-p53 Pathway in Tumor Suppression
The transcription factor E2F links the RB pathway to the p53 pathway upon loss of function of pRB, thereby playing a pivotal role in the suppression of tumorigenesis. E2F fulfills a major role in cell proliferation by controlling a variety of growth-associated genes. The activity of E2F is controlle...
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| Hauptverfasser: | , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
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MDPI AG
2023-12-01
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| Schriftenreihe: | Biology |
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| Online-Zugang: | https://www.mdpi.com/2079-7737/12/12/1511 |
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