A Decoy-Receptor Approach Using Nicotinic Acetylcholine Receptor Mimics Reveals Their Potential as Novel Therapeutics Against Neurotoxic Snakebite

Snakebite is a neglected tropical disease that causes 138,000 deaths each year. Neurotoxic snake venoms contain small neurotoxins, including three-finger toxins (3FTxs), which can cause rapid paralysis in snakebite victims by blocking postsynaptic transmission via nicotinic acetylcholine receptors (...

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Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Laura-Oana Albulescu, Taline Kazandjian, Julien Slagboom, Ben Bruyneel, Stuart Ainsworth, Jaffer Alsolaiss, Simon C. Wagstaff, Gareth Whiteley, Robert A. Harrison, Chris Ulens, Jeroen Kool, Nicholas R. Casewell
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Frontiers Media S.A. 2019-07-01
Rangatū:	Frontiers in Pharmacology
Ngā marau:	nicotinic acetylcholine receptors (nAChR) long-chain three-finger toxins (3FTx) acetylcholine binding proteins (AChBPs) snake venom neurotoxins envenoming therapeutics
Urunga tuihono:	https://www.frontiersin.org/article/10.3389/fphar.2019.00848/full
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!