A Decoy-Receptor Approach Using Nicotinic Acetylcholine Receptor Mimics Reveals Their Potential as Novel Therapeutics Against Neurotoxic Snakebite

Snakebite is a neglected tropical disease that causes 138,000 deaths each year. Neurotoxic snake venoms contain small neurotoxins, including three-finger toxins (3FTxs), which can cause rapid paralysis in snakebite victims by blocking postsynaptic transmission via nicotinic acetylcholine receptors (...

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Detalhes bibliográficos

Principais autores:	Laura-Oana Albulescu, Taline Kazandjian, Julien Slagboom, Ben Bruyneel, Stuart Ainsworth, Jaffer Alsolaiss, Simon C. Wagstaff, Gareth Whiteley, Robert A. Harrison, Chris Ulens, Jeroen Kool, Nicholas R. Casewell
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2019-07-01
coleção:	Frontiers in Pharmacology
Assuntos:	nicotinic acetylcholine receptors (nAChR) long-chain three-finger toxins (3FTx) acetylcholine binding proteins (AChBPs) snake venom neurotoxins envenoming therapeutics
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fphar.2019.00848/full
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