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Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11

Abstract Caspase-4 and caspase-11 (CASP4/11) sense bacterial lipopolysaccharide (LPS). Currently available inhibitors of CASP4/11 also block the activity of caspase-1 (CASP1), which restricts their usefulness in the study of CASP4/11 functions, as well as their clinical potential for the treatment o...

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Principais autores: Malvina Pizzuto, Mercedes Monteleone, Sabrina Sofia Burgener, Jakub Began, Melan Kurera, Jing Rong Chia, Emmanuelle Frampton, Joanna Crawford, Monalisa Oliveira, Kirsten M Kenney, Jared R Coombs, Masahiro Yamamoto, Si Ming Man, Petr Broz, Pablo Pelegrin, Kate Schroder
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Nature 2025-07-01
coleção:The EMBO Journal
Assuntos:
Cardiolipin
Noncanonical Inflammasome
Caspase-4
Caspase-11
LPS
Acesso em linha:https://doi.org/10.1038/s44318-025-00507-z
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