Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11

Abstract Caspase-4 and caspase-11 (CASP4/11) sense bacterial lipopolysaccharide (LPS). Currently available inhibitors of CASP4/11 also block the activity of caspase-1 (CASP1), which restricts their usefulness in the study of CASP4/11 functions, as well as their clinical potential for the treatment o...

Cijeli opis

Bibliografski detalji

Glavni autori:	Malvina Pizzuto, Mercedes Monteleone, Sabrina Sofia Burgener, Jakub Began, Melan Kurera, Jing Rong Chia, Emmanuelle Frampton, Joanna Crawford, Monalisa Oliveira, Kirsten M Kenney, Jared R Coombs, Masahiro Yamamoto, Si Ming Man, Petr Broz, Pablo Pelegrin, Kate Schroder
Format:	Artigo
Jezik:	Inglês
Izdano:	Springer Nature 2025-07-01
Serija:	The EMBO Journal
Teme:	Cardiolipin Noncanonical Inflammasome Caspase-4 Caspase-11 LPS
Online pristup:	https://doi.org/10.1038/s44318-025-00507-z
Oznake:	Dodaj oznaku Bez oznaka, Budi prvi tko označuje ovaj zapis!