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A TBC1D9-Rab29 axis controls homeostatic NF-κB signaling and selective IL-6 production in epithelial cells

BackgroundInterleukin-6 (IL-6) plays a crucial role in inflammation and immune defense; however, its intracellular trafficking and the mechanisms regulating its expression remain poorly understood.MethodsWe investigated epithelial cell responses to poly(dA:dT) stimulation and group A Streptococcus i...

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Autori principali: Xin Hu, Takashi Nozawa, Atsuko Minowa-Nozawa, Kazunori Murase, Ichiro Nakagawa
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2025-11-01
Serie:Frontiers in Cellular and Infection Microbiology
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Accesso online:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1688013/full
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