Sporadic cefiderocol resistance in Escherichia coli from the United Arab Emirates involves multifactorial mechanisms reversible by novel beta-lactamase inhibitors

Abstract Cefiderocol (CFDC), a novel siderophore-cephalosporin, is effective against multidrug-resistant (MDR) pathogens, but the emergence of resistance threatens its future use in treating infections. This study reports the emergence of CFDC resistance in four E. coli strains isolated from immunoc...

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Autori principali:	Farah Al-Marzooq, Hafsa Ahli, Rauda Aldhaheri, Omar Aleissaee, Abdulrahman Alzaabi, Abdullah Alsaadi, Hamad Almansoori, Akela Ghazawi, Lana Daoud, Amna Ahmad, Timothy Collyns
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2025-09-01
Serie:	Scientific Reports
Soggetti:	Cefiderocol Escherichia coli Whole-genome sequencing Beta-lactamase inhibitors
Accesso online:	https://doi.org/10.1038/s41598-025-19084-6
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