Investigation of Mechanistic Pathway for Trimethyl borate mediated Amidation of (R)-Mandelic Acid for the Synthesis of Mirabegron, an Antimuscarinic Agent

The present work describes investigation of mechanistic pathway for trimethyl borate mediated amidation of (R)-mandelic acid (3) with 4-nitophenylethylamine (2) to provide  (R)-2-hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylacetamide (4) during mirabegron synthesis.Plausible reaction mechanism is prop...

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Principais autores:	Vijayavitthal Thippannachar Mathad, Dattatray G. Deshmukh, Mukund N. Bangal, Mukunda R. Patekar, Vijay J. Medhane
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Slovenian Chemical Society 2018-03-01
coleção:	Acta Chimica Slovenica
Assuntos:	Trimethyl borate amidation α-hydroxy ester antimuscarinic drug mirabegron
Acesso em linha:	https://journals.matheo.si/index.php/ACSi/article/view/3632
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