Investigation of Mechanistic Pathway for Trimethyl borate mediated Amidation of (R)-Mandelic Acid for the Synthesis of Mirabegron, an Antimuscarinic Agent

The present work describes investigation of mechanistic pathway for trimethyl borate mediated amidation of (R)-mandelic acid (3) with 4-nitophenylethylamine (2) to provide  (R)-2-hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylacetamide (4) during mirabegron synthesis.Plausible reaction mechanism is prop...

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Hauptverfasser:	Vijayavitthal Thippannachar Mathad, Dattatray G. Deshmukh, Mukund N. Bangal, Mukunda R. Patekar, Vijay J. Medhane
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Slovenian Chemical Society 2018-03-01
Schriftenreihe:	Acta Chimica Slovenica
Schlagworte:	Trimethyl borate amidation α-hydroxy ester antimuscarinic drug mirabegron
Online-Zugang:	https://journals.matheo.si/index.php/ACSi/article/view/3632
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