Transmural APD heterogeneity determines ventricular arrhythmogenesis in LQT8 syndrome: Insights from Bidomain computational modeling.

Long QT Syndrome type 8 (LQT8) is a cardiac arrhythmic disorder associated with Timothy Syndrome, stemming from mutations in the CACNA1C gene, particularly the G406R mutation. While prior studies hint at CACNA1C mutations' role in ventricular arrhythmia genesis, the mechanisms, especially in G406R p...

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Bibliografski detalji

Glavni autori:	Simone Scacchi, Luca F Pavarino, Andrea Mazzanti, Alessandro Trancuccio, Silvia G Priori, Piero Colli Franzone
Format:	Artigo
Jezik:	Inglês
Izdano:	Public Library of Science (PLoS) 2024-01-01
Serija:	PLoS ONE
Online pristup:	https://doi.org/10.1371/journal.pone.0305248
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