Hereditary breast and ovarian cancer syndrome (BRCA) gene: Concept, pathways, therapeutics, and future

Hereditary breast and ovarian cancers are most commonly caused by mutations in BRCA1 and 2 genes. These are autosomal dominant mutations with high penetrance into subsequent generations. Affected individuals have deficiency in DNA repair mechanisms such as double strand DNA breaks (DSB) and non-homo...

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Autores principales:	Anup Tamhankar, Tanuja Tamhankar
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Thieme Medical and Scientific Publishers Pvt. Ltd. 2020-01-01
Colección:	Indian Journal of Medical and Paediatric Oncology
Materias:	brca syndrome brca protein inhibition chemosensitivity dna repair deficiency parp inhibitors
Acceso en línea:	http://www.ijmpo.org/article.asp?issn=0971-5851;year=2020;volume=41;issue=1;spage=9;epage=14;aulast=Tamhankar
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