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Clinical significance of hyaluronan levels and its pro-osteogenic effect on mesenchymal stromal cells in myelodysplastic syndromes

Abstract Background Hyaluronan (HA), a major component of the extracellular matrix, has been proven to play a crucial role in tumor progression. However, it remains unknown whether HA exerts any effects in myelodysplastic syndromes (MDS). Methods A total of 82 patients with MDS and 28 healthy donors...

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Main Authors: Cheng-Ming Fei, Juan Guo, You-Shan Zhao, Si-Da Zhao, Qing-Qing Zhen, Lei Shi, Xiao Li, Chun-Kang Chang
Format: Artigo
Language:Inglês
Published: BMC 2018-08-01
Series:Journal of Translational Medicine
Subjects:
Hyaluronan
Mesenchymal stromal cells
Osteogenic differentiation
Myelodysplastic syndromes
Online Access:http://link.springer.com/article/10.1186/s12967-018-1614-4
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