Mdm2 requires Sprouty4 to regulate focal adhesion formation and metastasis independent of p53
Abstract Although the E3 ligase Mdm2 and its homologue and binding partner MdmX are the major regulators of the p53 tumor suppressor protein, it is now evident that Mdm2 and MdmX have multiple functions that do not involve p53. As one example, it is known that Mdm2 can regulate cell migration, altho...
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| Autores principales: | , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Portfolio
2024-08-01
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| Colección: | Nature Communications |
| Acceso en línea: | https://doi.org/10.1038/s41467-024-51488-2 |
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