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Satellite Subgenomic Particles Are Key Regulators of Adeno-Associated Virus Life Cycle

Historically, adeno-associated virus (AAV)-defective interfering particles (DI) were known as abnormal virions arising from natural replication and encapsidation errors. Through single virion genome analysis, we revealed that a major category of DI particles contains a double-stranded DNA genome in...

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Principais autores: Junping Zhang, Xiangping Yu, Ping Guo, Jenni Firrman, Derek Pouchnik, Yong Diao, Richard Jude Samulski, Weidong Xiao
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2021-06-01
coleção:Viruses
Assuntos:
adeno-associated virus
subgenomic particles
“snapback” configuration
life cycle
Acesso em linha:https://www.mdpi.com/1999-4915/13/6/1185
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