The analgesic effects of triptolide in the bone cancer pain rats via inhibiting the upregulation of HDACs in spinal glial cells

Abstract Background Bone cancer pain (BCP) severely compromises the quality of life, while current treatments are still unsatisfactory. Here, we tested the antinociceptive effects of triptolide (T10), a substance with considerable anti-tumor efficacies on BCP, and investigated the underlying mechani...

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Detalhes bibliográficos

Principais autores:	Xiao-Fan Hu, Xiao-Tao He, Kai-Xiang Zhou, Chen Zhang, Wen-Jun Zhao, Ting Zhang, Jin-Lian Li, Jian-Ping Deng, Yu-Lin Dong
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2017-11-01
coleção:	Journal of Neuroinflammation
Assuntos:	Bone cancer pain Triptolide Antinociceptive effect Glial cell Histone deacetylase
Acesso em linha:	http://link.springer.com/article/10.1186/s12974-017-0988-1
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