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Inhibition of Histone Deacetylases Attenuates Morphine Tolerance and Restores MOR Expression in the DRG of BCP Rats

The easily developed morphine tolerance in bone cancer pain (BCP) significantly hindered its clinical use. Increasing evidence suggests that histone deacetylases (HDACs) regulate analgesic tolerance subsequent to continuous opioid exposure. However, whether HDACs contribute to morphine tolerance in...

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Principais autores: Xiao-Tao He, Kai-Xiang Zhou, Wen-Jun Zhao, Chen Zhang, Jian-Ping Deng, Fa-Ming Chen, Ze-Xu Gu, Yun-Qing Li, Yu-Lin Dong
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-05-01
coleção:Frontiers in Pharmacology
Assuntos:
bone cancer pain
morphine tolerance
HDACs
SAHA
MOR
Acesso em linha:http://journal.frontiersin.org/article/10.3389/fphar.2018.00509/full
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