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Esketamine attenuates bone cancer pain by suppressing MAPK signaling and glial activation in the spinal dorsal horn of rats

Abstract Bone cancer pain (BCP) is a debilitating condition driven by spinal neuroinflammation and glial activation. Esketamine (ESK), an NMDA receptor antagonist, exhibits analgesic effects beyond receptor blockade, but its mechanisms in BCP remain unclear. Here, a rat BCP model was established by...

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Principais autores: Liang Cheng, Dongjie Wang, Zhiqiang Zhang, Yu Zhang, Yunyun Tang, Kuibin Bao, Bin Guo, Kaijing Zhang, Yu Chen, Hui Ren, Chengfei Xu, Huadong Ni
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2026-02-01
coleção:Scientific Reports
Assuntos:
Bone cancer pain
Spinal dorsal horn
Esketamine
Glial activation
MAPK
Acesso em linha:https://doi.org/10.1038/s41598-026-38137-y
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