Osmotin-derived 9-amino-acid peptide alleviates α-synuclein and MPTP-induced glial cell activation mediated neuroinflammation, protecting dopaminergic neurons in Parkinson’s disease mice brain

Abstract Background Parkinson’s disease (PD) is the second most common neurodegenerative disorder, categorized by the loss of dopaminergic neurons in the brain’s Substantia Nigra pars compacta (SNpc) due to α-synuclein (α-syn) aggregation, leading to reduced dopamine levels in the striatum. This res...

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Principais autores:	Kyonghwan Choe, Muhammad Tahir, Min Hwa Kang, Hyun Young Park, Riaz Ahmad, Tae Ju Park, Myeong Ok Kim
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-01-01
coleção:	Journal of Biomedical Science
Assuntos:	Peptide osmotin-derived 9-amino-acid (Os_9aa) Parkinson’s disease (PD) Dopaminergic neuron α-synuclein (α-syn) 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Neuroinflammation
Acesso em linha:	https://doi.org/10.1186/s12929-026-01215-4
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