Osmotin-derived 9-amino-acid peptide alleviates α-synuclein and MPTP-induced glial cell activation mediated neuroinflammation, protecting dopaminergic neurons in Parkinson’s disease mice brain

Abstract Background Parkinson’s disease (PD) is the second most common neurodegenerative disorder, categorized by the loss of dopaminergic neurons in the brain’s Substantia Nigra pars compacta (SNpc) due to α-synuclein (α-syn) aggregation, leading to reduced dopamine levels in the striatum. This res...

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Ngā kaituhi matua:	Kyonghwan Choe, Muhammad Tahir, Min Hwa Kang, Hyun Young Park, Riaz Ahmad, Tae Ju Park, Myeong Ok Kim
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	BMC 2026-01-01
Rangatū:	Journal of Biomedical Science
Ngā marau:	Peptide osmotin-derived 9-amino-acid (Os_9aa) Parkinson’s disease (PD) Dopaminergic neuron α-synuclein (α-syn) 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Neuroinflammation
Urunga tuihono:	https://doi.org/10.1186/s12929-026-01215-4
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