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Excessive IL-4 environment enhances osteoclastogenesis and modulates inflammatory cell differentiation in bone loss associated with food allergic enteropathy

Background: Severe Th2 inflammatory diseases, including food allergy, are known to be associated with osteoporosis. However, while IL-4 inhibits osteoclast differentiation, detailed mechanisms of osteoporosis caused under IL-4-excessive environments remain unclear. Methods: OVA23-3 mice are transgen...

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Huvudupphov: Kohei Soga, Tomohiro Hoshino, Masato Tamai, Akemi Itoh, Satoru Uno, Kosuke Nishitsuji, Masaaki Hashiguchi, Shotaro Nakamura, Ryo Isogaki, Kotaro Takane, Fuka Yamazaki, Atsushi Furuhata, Shigeru Kakuta, Shuji Matsuoka, Michio Tomura, Naoki Shimojo, Satoshi Hachimura, Haruyo Nakajima-Adachi
Materialtyp: Artigo
Språk:Inglês
Utgiven: Elsevier 2026-04-01
Serie:Allergology International
Ämnen:
CD4+ T cells
Food allergy
Interleukin-4
Myeloid cells
Osteoporosis
Länkar:http://www.sciencedirect.com/science/article/pii/S1323893025001261
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