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Hyperactivity of medial prefrontal cortex pyramidal neurons occurs in a mouse model of early-stage Alzheimer’s disease without β-amyloid accumulation

The normal function of the medial prefrontal cortex (mPFC) is essential for regulating neurocognition, but it is disrupted in the early stages of Alzheimer’s disease (AD) before the accumulation of Aβ and the appearance of symptoms. Despite this, little is known about how the functional activity of...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Nasreen Choudhury, Lihua Chen, Lena Al-Harthi, Xiu-Ti Hu
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2023-07-01
Saila:Frontiers in Pharmacology
Gaiak:
Sarrera elektronikoa:https://www.frontiersin.org/articles/10.3389/fphar.2023.1194869/full
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