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Methamphetamine and neuroHIV suppress astrocytic potassium channel function in the medial prefrontal cortex via different mechanisms

IntroductionMethamphetamine (Meth) is a highly addictive psychostimulant that disrupts neuronal function in the medial prefrontal cortex (mPFC), inducing Meth use disorders (MUD). MUD is often complicated by HIV-associated neurocognitive disorders (HAND, a.k.a. neuroAIDS/neuroHIV), and vice versa. M...

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Principais autores: Lihua Chen, Stefanie L. Cassoday, Joao I. Mamede, Lena Al-Harthi, Xiu-Ti Hu
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-11-01
Serier:Frontiers in Pharmacology
Fag:
astrocyte
methamphetamine (METH)
neuroHIV
medial prefrontal cortex (mPFC)
K+ channel
electrophysiology
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2025.1691165/full
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